Thursday 31 January 2013

HEALTH CARE IN MALAYSIA



HEALTH CARE IN MALAYSIA   -   A critical review

Introduction :
Jose Marc Castro is a Pilipino, based in Philippines.  He has been a contributing writer and researcher on ExpatForum.com since 2007.  His legal background gives him the ideal skills needed to research and write great and useful material for expatforum.com.

The writer give positive remarks about healthcare in Malaysia.  Jose emphasize that Malaysia is fortunate country where health care had been improving over the years and Jose encourage tourist from other countries to consider  Malaysia for their medical care destination, where Malaysia is embarking of medical tourism as part of the country’s wish.  Eventhough there were issues mentioned by the writer, however those issues were not only persist in Malaysia but are common within Asian countries.
I personally agree to Jose’s writing about overall healthcare in Malaysia, eventhough there are some setbacks, overall Jose post more of positive points and promote the Malaysian healthcare system.  Jose made it clear in his second paragraph that going to Malaysia for healthcare is never a hassle.

Summary
Jose praised Malaysia as healthcare tourist destination, with its high-end hospitals that provide the best services.  Entering Malaysia is simple and easy, more over for healthcare matter.  The writer emphasized that Malaysia through the private and public sectors provided comprehensive and sufficient coverage of medical needs for its population.   The number of  health colleges and schools is enough to attest that Malaysia is serious on the on-going improvement  of its healthcare system to provide the quality health care.

To make the foreigner comfortable, he also mentioned of Malaysian various ethnics groups which carry different cultures which he described to be an interesting customs and vibrant cultures.  Another important issue which gives credit to the Malaysian healthcare system, mentioned by the writer is that the Malaysian healthcare system also encouraged foreign doctors to share their expertise in Malaysia, by working in Malaysian hospitals.  This is exactly true that not only private hospitals employ foreigners, but also the government hospitals do have foreign specialist contributing to the number of expert in government hospitals.  The writer also mentioned specifically that the quality health care are being provided not only to its residents but also to tourists, emigrants and visitors as well.  Presently, eventhough the private hospitals are set to make profit from needy patient, the cost is still affordable for the medical procedures and also the accommodations.

Critique
The writer, a Pilipino with legal background had written not less than six articles of the same nature but for various countries.  He wrote on – Health Care in Malaysia as this one we are reviewing, other articles are on Cyprus, Dubai, Hong Kong, Japan, UK, Thailand and also his homeland, Philippines.
Going through his writing on his own country and what he wrote on Malaysia, seemed that he is not biased on his comments and opinion.  He gave good remarks on Malaysian standard of healthcare.
His comment which is not agreeable to me is that the modern healthcare in Malaysia was due to Malaysia being a British colonial, whereby modern and western medical practices were being introduced due to the colonialism.  He mentioned that the medical care were being transferred from the British colonial rules to meet the growing needs.
Actual fact, the growth and improvement of Malaysian healthcare was due to the positive growth of the Malaysian economy that give room for better healthcare standard.  Growth of the economy have lead to better standard of living and created the high needs for better healthcare. 

On two negative comments he made on the issues on Malaysian healthcare,  eventhough we may not like it, but it is the truth that the writer commented.  First was the common issues he mentioned which is rampant even to neighboring countries, that is some doctors who have their mind-set to gain much money from their patients.  Secondly, was the growth of modern hospitals was almost all at the urban areas, leaving the remote area with less fortunate medical care facilities.  

Other than those mentioned above, his comment on Malaysian healthcare system and policy was overall better than many other countries in the region.  He praised Malaysian Government on the commitment to provide high-quality health care for the public whether they are locals or foreigners.
The growth and establishment of the various medical schools in the Malaysia is the confirmation that Malaysia is really serious to provide high quality health care to the public.  Medical practitioners in Malaysia are not only those who studied in Malaysia, but also from other parts of the world including universities from US.
The writer also mentioned that hospitals in Malaysia are considerably the best with the latest medical equipments for optimum performance.  A very strong point mentioned here was also that Malaysia have medical practitioners who earned their degrees from universities in US.  This kind of remark is very important for Malaysia that will boost confidence to foreigners to have their medical treatment in Malaysia.

Conclusions
This article helps Malaysia market it’s medical tourism destination. The many positive points given by the writer as against the few negative issues is much acceptable.   Overall this article is short and simple, easy to understand and the message he expressed in this article is precisely clear to all, whoever read it will understand and will assist in one’s need for a medical treatment.

Welcome to Malaysia.
Published at :
by  :  JOSE MARC CASTRO on August 8, 2009.

Wednesday 30 January 2013

TELERADIOLOGY AND PACS


1.    INTRODUCTION
      Teleradiology is the electronic transmission of radiologic images from one location to another for the purpose of interpretation or consultation.  These radiological patient images include x-rays, CTs, and MRIs.  Teleradiology may allow more timely interpretation of radiologic images and give greater access to secondary consultations.  With teleradiology, users in different location may at the same time view images.  Many reported that teleradiology improve patient care by allowing radiologist to provide service without having to be at patient location.  Teleradiology allows specialist to be available 24 hours. 
      Teleradiology utilizes standard technologies such as the internet, telephone line, wide area network, local area network (LAN) and the latest high tech being computer clouds (Wikipedia, 2012).  There is a specialized software that used to transmit the images and allow the Radiologist to analyze hundred of images for a given study.  Recent research on teleradiology, (Wikipedia, 2012) have shown technologies such as advanced graphic processing, voice recognition, and image compression are often used.    
      The use of teleradiology reflects the changing world of clinical practice, service delivery and technology.  Nowadays, the delivery of health is changing and teleradiology is part of that change, which also includes the globalization of radiology. 
      Teleradiology aims to even radiologists’ workload, ensure on call services, reduce waiting lists, consult other specialists and cut costs (Ross, Sepper and Pohjonen, 2009).  Other benefits of teleradiology include rationalize on-call services, to improve the reporting capacity of health care organizations, to balance the workload across radiologists or domestic health care institutions, and to link remote imaging facilities with a central hospital  (Ross, Sepper and Pohjonen, 2009). 
      A picture archiving and communication system (PACS) perform the tasks like taking in images, archiving images, and sends the images to workstation for display, while saving the images and shall not lose them.  Every system had the ability to zoom, pan, window and level.  Other than that, they can even flip and rotate images and every system also have measurement tools. 
      A PACS consists of four major components.  These components are the imaging modalities such as x-ray plain film, CT and MRI, a secured network for the transmission of patient information, workstations for interpreting and reviewing images, and archives for the storage and retrieval of images and reports. 
      Most PACS handle images from various medical imaging instruments including ultrasound, magnetic resonance (MR), positron emission tomography (PET), computed tomography (CT), endoscopy, mammograms, digital radiography, computed radiography (CR), ophthalmology, and many more. 
      In the early days of PACS, that was considered plenty.  Over time people start to look more into PACS and modify the system they had designed to do more work of a radiology department for the future and some can even turn 2D images into 3D images. 



2.    LITERATURE REVIEW
      From the research (Lundberg, Wintell and Lindskold, 2009) showed the global demand for teleradiology is increasing because of the shortage of highly trained radiologists who can provide the services needed in healthcare today.  
      Recent research (Ng, Wang and Ng, 2006) showed that multimedia messaging service (MMS) mobile phone technology offers a simple, cheap, quick, and effective solution to the problem of scan interpretation.  Other than that, the MMS technology is demonstrated to be a useful media for the transmission of high quality images to assist in the diagnostic process and implementation of emergent clinical therapy.
      From study of (Reponen et al., 2005), the researchers noted that electronic patient record (EPR) and PACS can be connected to wireless terminals which deliver information to the point of care.  Throughout their studies, the researchers used mobile teleradiology using special type mobile phones such as smartphones and personal digital assistant (PDA) with phone functions to deliver information.  Result shows these terminals are feasible for emergency situations and mostly for evaluation of neurosurgical CT images.
      Recent research (Pallamar et al., 2012) showed digital mammography images can be transferred from one location to another via data link.  However, there are technical limitations due to limited transmission capacities and some centers overcome these by compressing images for transmission.  So researchers did the study to demonstrate the feasibility of sending uncompressed digital mammogram, and the result shows uncompressed digital mammograms can be transmitted to different institutions with different workstation, without loss of information and the transmission process does not significantly influence image quality, lesion detection, or BIRADS rating. 
      Teleradiology has been practiced to certain extent for more than two decades.  However, the real boost of cross border service has not been achieved (Ross, Sepper and Pohjonen, 2009).  So, from (Ross, Sepper and Pohjonen, 2009) done the research on cross border teleradiology to find out the possible challenges in building a cross border teleradiology service.  The researcher found that cross border teleradiology is currently a narrow service limited by the linguistic barriers, trust and legal issues and the most important challenge is to ensure that teleradiology does not in any way reduce the quality of radiology services provided to the citizen (Ross, Sepper and Pohjonen, 2009). 
      Binkuysen and Ranschaert (2010) noted that in their survey, reasons to make use of teleradiology services can be a growing or changing workload, a structural or temporary shortage of radiologists, and a shortage of expertise.  In some situations teleradiology is also used for educational purposes.  According to their study, the most common purpose of teleradiology is to transmit images to radiologists at home, to ease the burden of being on-call.
      Recent research of Benjamin, Aradi and Shreiber (2009) spotted that the nighthawk service helps radiology groups improve their quality of life by outsourcing their off-hours, on-call duties, to a third party.  It is estimated that more than 50 percent of US radiology groups now use this service and the main use of nighthawks is for emergency radiology (Benjamin, Aradi and Shreiber, 2009).  Based on the commercial success of nighthawk teleradiology services, a new ‘dayhawk’ market is emerging and still on studies by researchers.
      Jarvis and Stanberry (2005) noted that teleradiology is a powerful tool, now available to complement the practice of clinical radiology, to make radiology more universally available, to speed diagnosis and management, and to assist in obtaining specialist opinions.  Nowadays, noted the presence of a robust teleradiology link to home, especially when an extension of PACS transmit a full range of radiology imaging.  The casualty officers and on call junior doctors will have immediate access to a consultant opinion at home 24 hours and this can develop into an on call from home hot reporting service which may be advantageous to the staff in the hospital, and often to the patients (Jarvis and Stanberry, 2005).
      The early PACS implementations focused primarily on providing the basic PACS functions such as image retrieval and viewing (Wetering and Batenburg, 2008).  However with the trends towards PACS integration optimization many technological advances are made and some emerging technologies such as computer-assisted reading (CAR) and computer-aided diagnosis can be incorporated.    
      Sutton (2010) stated that by implement full hospital-wide PACS in all hospitals, this placed UK in a strong position to facilitate full national data sharing across all healthcare organizations to improve patient care.
      Hirschorn and Dreyer (2010) mentioned that 3D or advanced visualization has already happened in some PACS.  PACS have incorporated not only the basic 3D manipulations of MPR and MIP, but also vessel tracing for angiographic studies, virtual endoscopic views for flying through hollow viscera like the trachea or intestines, and surface rendering for complex fractures such as those of the tibial plateu, including the ability to remove unwanted bones that obscure the view, like the femoral condyles (Hirschorn and Dreyer, 2010).
                  Bellon et al., (2010) talked about the advantages of PACS where with PACS image related information can be easily accessed throughout the entire hospital or even beyond as the most important product in a hospital is information when the very purpose of radiology is to provide information that later will be combined with other information and lead to decision or therapy plans.  The researchers also look at the factors that influence the design of tomorrow’s systems, especially those in larger multidisciplinary hospitals.
      Recent research (Faggioni et al., 2010) discovers the advanced technology attains to improved PACS performance.  One of these is holographic PACS for enhanced speed and storage.  According to Faggioni (2010), holographic media are an emerging technology which could overcome the physical barriers to approach data storage through a powerful combination of high storage transfer densities and fast data transfer rate.
      Kari et al., (2005) noted that presentations of multi-modality images, tele-conference and the electronic archival are playing significant role in the routine clinical work.  Researcher did the study on WEB based teleradiology where in several external institutes are WEB based connected to the central archives and can access the necessary or available modalities.  The systems offer advantages in medical consultations of radiologists and clinical partners.  Other advantages is evident in graduate and continuous postgraduate trainings where a training database has been installed on a server providing training and learning possibilities in order to get more experiences with the tele-evaluation (Kari et al., 2005).   

3.    DISCUSSION
3.1 Advantages and Benefits of Teleradiology and PACS
      Presently, more often there is a need to share data between different hospital in a region.  The problem is that different hospital use different PACS system.  Because of different PACS system used, some images or data are not allowed to be displayed or archived in other hospital.  Because of this, (Fernandez-Bayo, 2010) conduct a study and recommend one approach to solve this problem where he noted that the best approach is to use integration standards and follow the Integrating of Healthcare Enterprise (IHE).  According to Fernandez-Bayo (2010), IHE is an initiative by the healthcare industry and institutions to improve the way healthcare computer systems share information.  IHE allows sharing images from different hospitals even if they have different PACS system.  Fernandez-Bayo (2010) noted that among the different solutions available to share images between different hospitals, IHE organization presents the Cross Enterprise Document Sharing profile
(XDS).  The advantage is images do not need to be duplicated in a central archive to be shared among the different healthcare organizations, they only need to be indexed and published in a central registry.  Other benefits by using this system includes allowing everybody in the hospital to consult and add information and also prevent the partial or total loss of the patient’s information.  This system also opens the possibility of setting up telemedicine projects where the data can be shared among different centers or hospitals.
      According to Binkuysen and Ranschaert (2010), ten years ago image quality, transmission speed, and image compression were important issues in teleradiology.  However, today the focus is on clinical governance, medico-legal issues, and quality assessment.  In the future there will be no distinction between PACS and teleradiology.  Virtual imaging organizations will become reality.
      Nowadays, in many institutions there is a growing tendency towards overflow of workload, because the demand for imaging procedures is increasing.  Teleradiology should be able to solve this type of overflow problems.  Now, with full hospital-wide PACS, allows professional healthcare for viewing access not only within the diagnostic imaging department but also within outpatient clinics and the wards.  According to Sutton (2010), the benefits of this full implementation of a trust wide PACS became clear to all who had introduced PACS into the healthcare environment in terms of patient management, reporting efficiencies and wider organizational improvements thus can reduce workload.
      In some countries, the role of teleradiology also included that images can be transmitted to other organizations within or outside the country for the purposes of reporting.  However, there is a reporting standards set by department of health in terms of technical quality and accuracy, to provide high quality service.  Sutton (2010) noted that by implement this, there has been a dramatic fall in the number of patients waiting.  Because most of the problem in diagnostic imaging there is always lack of imaging capacity, lack of radiologists for reporting and poor working practices which increase patient’s waiting time.
3.2 Gadget Used for Teleradiology
      Ridley (2012) reported that from John Hopkins School of Medicine, researcher did the study to compare between PACS and IPad in diagnostic accuracy for detecting pulmonary embolism in emergency situation.  From the study, result shows no difference between the use of IPad and PACS workstation in diagnostic.  IPad also seemed like a faster method of display which is good for patient with pulmonary embolism who needs emergency treatment.  If the patient is required to be transferred to another hospital for treatment, the secondary consultant shall not waste time to review the images by loading the CD to computer, but they can only see from IPad where previous consultant sent the images. 
      Other than IPad, smartphone also seemed to have advantage for emergency treatment.  In one study about effective treatment of stroke patients, Ridley (2012) reported that therapy could be delivered more quickly by physicians who are able to diagnose stroke patients simply by whipping out their smartphones.  The physicians, wherever they are can interpret the CT brain images by viewing images on a smartphone sent by radiologist, rather than waste time to wait for that CT films to be sent to the clinic to review.  Thereby, evaluation and treatment completion turnaround time can be reduced.  
      In hospital, the problem usually occur after office hour when most of the expertise or senior doctors not available in hospital.  Most patients being sent to emergency department for diagnosis are attended only by medical officer.  Diagnosis is highly dependent on accurate interpretation of scans by experienced clinicians (Ng, Wang and Ng, 2006).  Because of that, the researcher did the study on multimedia messaging service (MMS) teleradiology to provide emergency neurosurgical service.  Ng, Wang and Ng (2006) noted that MMS takes only a few minutes to send and receive and allow senior doctors to view important images and make important clinical decisions to enhance patient management in an emergency situation.  With MMS, medical officer can take the relevant images directly from the mobile phone from the PACS, off the computer screen and send to the expertise to review.  By doing this, the expertise can quickly informed medical officer about the emergent clinical decision making, and this will improved level of confidence of both side.     
3.3 Technological Advances With PACS
      During the earlier days, PACS can only be used for image viewing and retrieval.  Nowadays many technological advances are made for the future PACS in terms of technical requirements such as computer-assisted reading (CAR) and computer-aided diagnosis (CAD) and central image provider for post-processing and workflow of clinical and research medical images.  Now as medical imaging became important to other departments outside radiology, PACS has become a clinical collaboration tool.   
      From recent research (Wetering and Batenburg, 2008), one of technological advances in PACS is computer-assisted bone age assessment which can be integrated with clinical PACS for advanced image analysis purposes.  Radiologist or radiographer can assess patient’s bone age by using CAD developed based on phalangeal and carpal bone growth in PACS. 
      Other technological advance in PACS is CAD and cuing and the adoption of intelligent application of informatics.  Noted that the adoption of CAD will become routine in the coming years, especially in the detection of lung nodules and breast cancers.
      Wetering and Batenburg (2008) spotted that full field digital mammography (FFDM), benefit of computer-aided detection, computer-assisted classification and PACS can be realized.  FFDM requires high resolution monitors to enable the physicians to visualize the minute details for accurate diagnosis, so PACS with the integration and application of breast imaging are associates with several challenges to provide required image display and interpretation, communication and storage.
       As of now the days of 2D PACS are numbered.  3D PACS are the latest way to go for now and into the future.  According to Hirschorn and Dreyer (2010), three-dimensional (3D) imaging services as well as the workflow involved in combination of 3D imaging services with PACS and radiology information systems are serious challenges for hospitals nowadays and to the future.   However, Faggioni et al., (2010) noted that another advanced possibility is 4D imaging which is useful especially in cardiac radiology to evaluate the function of the myocardium or the cardiac valves.  Beyond that, a shift in the near future toward 5D data which for instance, metabolic data by means of radiolabelled tracers (Faggioni et al, 2010) and advanced PACS systems should be able to handle this kind of information.   
      Another advance technology in PACS is image-assisted surgery system (IASS) which is designed on the concept of an image-integrated electronic patient record (EPR) and used of existing knowledge of PACS and the associated medical imaging informatics infrastructure (Wetering and Batenburg, 2008).  This IASS allows patient centered images and data to be staged at the server and delivered to the workstation for review before, during and after surgery.
      Intelligent data mining will also take on greater importance with PACS which is another advance in PACS.  Intelligent data mining allows image processing and data extraction that will ease the interpretation process for radiologists.  Mining objects include radiology reports, correlative imaging studies and electronic medical records.
      For today and for the future development, the researchers discover the SuperPACS.  The SuperPACS merges the capabilities of PACS and teleradiology services and allows radiology groups serving multi-sites to work efficiently both locally and remotely and fully satisfy the physicians, patients, and hospital administrators expectations.  This efficiency means the ability to deliver the radiologist’s end product, the report with maximum speed and accuracy under any business scenario.
      The problem with PACS is when there is a huge volume of data such as cardiac ultrasound and angiography which generate hundreds of MB of data for each study to be transferred to PACS and to keep these exams permanently available.  However Costa et al. (2008) stated that there is a Web-enabled PACS software solution that is specially oriented to support demanding cardiac imaging laboratories.  It provides a cost efficient digital archive, ensures full online availability of studies and simplifies the transmission of medical data over the internet.
      Howell (2012) reported that there is a new system in PACS called vendor neutral archives (VNAs).  VNAs offer many departments and practices perfect and seamless image storing and archiving capability across any PACS.  VNAs were created when there was a complaint on PACS where PACS cannot share images with other departments and cannot migrate studies to another facility.  There is also a new emerging protocol called medical imaging network transport (MINT).  When MINT and VNAs being merged, it gives more advantages to doctors and patients.  For example, when doctors want to know whether that child has had a CT at another hospital so they don’t duplicate that study, they can use this new system.  This could keep radiation doses as low as they can for kids.         

3.4 Security and Privacy in Teleradiology
      There is one problem in teleradiology, which is a legal issue.  Modern teleradiology means more and more cross organizational or even cross border service which can create a legal issue problem.  For past years, many system developers do not know how to create a security concept.  Recent research (Ruotsalainen, 2009) defined the requirements needed to make different teleradiology models trusted.  Those requirements include a common security policy, common security and privacy protection principles and requirements, controlled contracts between partners and the use of security tools.  Today onward there is a security and privacy protection requirements, controls, safeguard and security services which make modern teleradiology being trusted in such a way that confidentiality, integrity and availability of information.
      In case of legal issue, patients have the right to sue the radiologist and the company.  According to Bonmati, Morales and Bach (2011), the radiologist is required to subscribe to a liability insurance which shall protect radiologists from economic loss if they are being sued in relation to their professional activities.  Also in the case of teleradiology, it is necessary to subscribe for an insurance cover for this type of activity and guaranteeing coverage in all countries where it is carried out (Bonmati, Morales and Bach, 2011).  The teleradiology service must always guarantee patient confidentiality and must comply with the data protection law of the countries of origin and destiny.     
        
                          
4.    CONCLUSION
      Teleradiology has become more accessible and feasible to physicians with the helped of PACS. 
      Through teleradiology, images can be sent to another part of the hospital, or to other locations around the world.  Other than transmitting images and information, teleradiology also consists of sharing knowledge and working together in a network.  It helps rapid access to radiological reports and second opinions, remote consulting among physicians, improved patient care, access to complex tools for post processing and computer-aided diagnosis, support for research and training projects, tie between isolated healthcare providers and busier or more experienced providers, 24 hour coverage, and competition among radiology departments. 
      The use of teleradiology eliminates the need to travel from home to the hospital and can be used to consolidate calls between multiple locations. It is a strategy that radiologists have widely adopted to meet the changing needs of their practices.  One radiologist can potentially cover a number of locations where there might not be enough work for a full-time radiologist, and one subspecialist can potentially provide consultations for patients in many practice locations. 
      Shortage of radiologists, increase use of advanced imaging methods, the consolidation of hospitals into regional delivery systems, and high expectations of patients and referring physicians for timely service are the factors that encourage the increasing use of teleradiology.  These factors also helped to create the new and potentially disruptive business models for service delivery that can be viewed as threats and opportunities.
      Radiologists also need to recognize and accept the changes in organizational structure while the service expectations are taking place in the health care system through the availability of teleradiology and PACS.  No matter what happens to the economy, the needs of digital imaging are not going away and cannot be ignored.  Because of this teleradiology is here to stay and should be considered as the future of healthcare delivery although some issues still need to be addressed.
5.    RECOMMENDATION
      Most hospitals in Malaysia have switched from film to fully digital with PACS.  Now in  Malaysia is also moving towards the new era of teleradiology and PACS.  However, there are still limitation in terms of financial and quality of life that affect the development of teleradiology.  More research are required to be conducted in Malaysia regarding teleradiology and PACS to alert all the healthcare organization about the benefit of teleradiology. 
      Other than hospitals in city area, smaller hospitals in rural area are also required to provide PACS system and teleradiology so that patients in rural area can get the same benefit as patients in urban areas and cities. 
      Department of health in Malaysia should adopted some agenda to maximize the benefits of existing IT systems and promote improved patient care and productivity in the healthcare industry. 


6.    REFERENCES

Bellon et al., 2010. European journal of radiology, Trends In PACS Architecture, [e-journal] 78(2), Available through: ScienceDirect website <http://www.elsevier.com/locate/ejrad> [Accessed 08 December 2012]

Benjamin, M., Aradi, Y. and Shreiber, R., 2009. European journal of radiology, From Shared Data To Sharing Workflow: Merging PACS And Teleradiology, [e-journal] 73(1), Available through: ScienceDirect website <http://www.elsevier.com/locate/ejrad> [Accessed 08 December 2012]

Binkhuysen, F.H.B. and Ranschaert, E.R., 2010. European journal of radiology, Teleradiology: Evolution and Concepts, [e-journal] 78(2), Available through: ScienceDirect website <http://www.elsevier.com/locate/ejrad> [Accessed 10 December 2012]

Bonmati, L.M., Morales, A. and Bach, L.D., 2011. Update in radiology, Toward the Appropriate Use of Teleradiology, [e-journal] 54(2), Available through: PubMed website <http://www.ncbi.nlm.nih.gov/pubmed/ 21958724> [Accessed 10 December 2012]
Costa et al., 2008. Computer methods and program in biomedicine, Design, Development, Exploitation and Assessment of A Cardiology Web PACS, [e-journal] 93(3), Available through: Elsevier website <http://www.intl.elsevierhealth.com/journals/cmpb> [Accessed 08 December 2012]
Faggioni et al., 2010. European journal of radiology, The Future Of PACS In Healthcare Enterprises, [e-journal] 78(4), Available through: ScienceDirect website <http://www.elsevier.com/locate/ejrad> [Accessed 13 December 2012]
Fernandez-Bayo, J., 2010. European journal of radiology, IHE Profiles Applied To Regional PACS, [e-journal] 78(11), Available through: ScienceDirect website <http://www.elsevier.com/locate/ejrad> [Accessed 12 December 2012]
Hirschorn, D. and Dreyer, K.J., 2010. Diagnostic imaging, 2D PACS Has Had Its Day In The Sun, Now 3D PACS Is Moving In, [online] Available at: <http://www.diagnosticimaging.com/display/article/113619/1575318> [Accessed 10 December 2012]
Howell, L.J., 2012. Diagnostic imaging, VNAs Releasing Radiology Images from PACS Jails, [online] Available at: <http://www.diagnosticimaging.com/informaticspacs/content/article/113619/2096520> [Accessed 10 December 2012]
Jarvis, L. and Stanberry, B., 2009. Clinical radiology, Teleradiology: Threat or Opportunity?, [e-journal] 60(8), Available through: PubMed website <http://www.ncbi.nlm.nih.gov/pubmed/16039919> [Accessed 10 December 2012]
Kari et al., 2005. International congress series, Clinical Evaluation of Multi-Modality Image Archival and Communication System In Combination of WEB Based Teleradiology, [e-journal] 1281(3), Available through: Elsevier website <http://www.intl.elsevierhealth.com/journals/ijmi> [Accessed 08 December 2012]
Lundberg, N., Wintell, M. and Lindskold, L., 2009. European journal of radiology, The Future Progress of Teleradiology—An Empirical Study In Sweden, [e-journal] 73(1), Available through: ScienceDirect website <http://www.elsevier.com/locate/ejrad> [Accessed 15 December 2012]
Ng, W. H., Wang, E. and Ng, I., 2007. Surgical technology, Multimedia Messaging Service Teleradiology In The Provision Of Emergency Neurosurgery Services, [e-journal] 67(4), Available through: ScienceDirect website <http://www.elsevier.com/locate/ejrad> [Accessed 13 December 2012]
Pallamar et al., 2012. European journal of radiology, Teleradiology With Uncompressed Digital Mammograms: Clinical Assessment, [e-journal] Available through: Elsevier website <http://www.elsevier.com/locate/ejrad> [Accessed 20 December 2012]


Ridley, E.L., 2012. AuntMinnie, In An Emergency, IPad Can Handle Pulmonary Embolism, [online] Available at:<http://www.auntminnie.com//index> [Accessed 05 December 2012].
Ridley, E.L., 2012. AuntMinnie, Teleradiology In Your Pocket: Smartphone Boosts Stroke Treatment, [online] Available at:<http://www.auntminnie.com//index> [Accessed 05 December 2012].
Reponen et al., 2005. International congress series, Mobile Teleradiology With Smartphone Terminals As A Part Of A Multimedia Electronic Patient Record, [e-journal] 1281(3), Available through: Elsevier website <http://www.intl.elsevierhealth.com/journals/ijmi> [Accessed 08 December 2012]
Ross, P., Sepper, R. and Pohjonen, H., 2010. European journal of radiology, Cross-Border Teleradiology—Experience From Two International Teleradiology Projects, [e-journal] 73(1), Available through: ScienceDirect website <http://www.elsevier.com/locate/ejrad> [Accessed 13 December 2012]
Ruotsalainen, P., 2009. European journal of radiology, Privacy And Security In Teleradiology, [e-journal] 73(1), Available through: ScienceDirect website <http://www.elsevier.com/locate/ejrad> [Accessed 08 December 2012]
Sutton, L.N., 2010. European journal of radiology, PACS and Diagnostic Imaging Service Delivery—A UK Perspective, [e-journal] 78(2), Available through: ScienceDirect website <http://www.elsevier.com/locate/ejrad> [Accessed 12 December 2012]
Wetering, R. and Batenburg, R., 2008. International journal of medical informatics, A PACS Maturity Model: A Systematic Meta-analytic Review On Maturation and Evolvability of PACS in the hospital enterprise, [e-journal] 78(2), Available through: Elsevier website <http://www.intl.elsevierhealth.com/journals/ijmi> [Accessed 15 December 2012]

PANCREATIC CARCINOMA




1.      INTRODUCTION

1.1              Definition Of Pancreatic Carcinoma
            From the pancreas (2011), the author noted that the pancreas is an organ located deep in the abdomen between the stomach and the spine.  The pancreas is about 6 inches long.  The largest part of the pancreas is the head, the middle section is the body, and the thinnest part is the tail. 
            The function of the pancreas is to release enzymes into the intestines that help the body absorb foods (pancreatic carcinoma, 2011).  The pancreas also makes insulin and other hormones.  These hormones enter the bloodstream and travel all over the body.  They help the body use or store the energy that comes from food (the pancreas, 2011). 
            Pancreatic carcinoma is cancer of the pancreas which is a malignant neoplasm originating from transformed cells arising in tissues forming the pancreas (pancreatic cancer, 2012).  From what is pancreatic cancer? Pancreatic cancer and causes (2012), the author stated that pancreatic cancer occurs when there is uncontrolled cell growth begins in the pancreas.  These abnormal cells continue dividing and form masses of tissue called tumors.  A benign tumor stays in one spot and demonstrates just a limited growth.  Malignant tumors form when the cancer cells migrate to other parts of the body through the blood or lymph systems.  It is said to have metastasized if a tumor successfully spreads to other parts of the body and grow, invading and destroying other healthy tissues (what is pancreatic cancer? Pancreatic cancer and causes, 2012). 
1.2              Etiology
            Dragovich (2012) noted that pancreatic cancers can arise from the exocrine and endocrine portions of the pancreas, but 95 percent of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.
            The exact cause of pancreatic cancer in unknown (pancreatic cancer, 2012).  There are some researchers wrote that pancreatic cancer is caused by DNA mutations and also other risk factors. Some of the risk factors include cigarette smoking, age, race, gender, religious background, chronic pancreatitis, diabetes, obesity, diets, and genetics (what causes pancreatic cancer, 2012).  Mostly researchers agree that pancreatic cancer is slightly more common in women than in men. The risk of pancreatic cancer increases with age and a small number of cases are related to genetic syndromes that are passed down through families (pancreatic cancer, 2012).
1.3              Sign and Symptoms
            Nugent and Stuart (2012) noted in their article, early symptoms for pancreatic cancer can be absent because it often grows silently for month before it is discovered and the symptoms will develop when the tumor grows large enough and press on other nearby structures such as nerves, the intestines, and bile ducts.  When the tumor press on nerves, this will causes pain.  While on intestines, the affects will be loss of appetite, nausea, and weight loss and when the tumor press on bile ducts, this will causes jaundice and can also cause loss of appetite and itching (Nugent & Stuart, 2012).
            However, from pancreatic cancer symptoms (2012), the author stated that symptoms of pancreatic cancer depend on the cancer’s location within the pancreas.  The author noted that pancreatic cancer in the head of the pancreas is likely to cause symptoms such as weight loss, jaundice, dark urine, light stool color, itching, nausea, vomiting, abdominal pain, back pain, and enlarged lymph nodes in the neck but pancreatic cancer in the body or tail of the pancreas usually causes belly or back pain and weight loss.  
1.4              Pathophysiology
            Dragovich (2012) noted that pancreatic cancer, usually first metastasizes to regional lymph nodes, then to the liver, and less commonly, to the lungs. It can also directly invade surrounding visceral organs such as duodenum, stomach, and colon.  Other than that, it can metastasize to any surface in the abdominal cavity via peritoneal spread.  Ascites may result.  Pancreatic cancer also may spread to the skin as painful nodular metastases (Dragovich, 2012).
1.5              Treatment
Nugent and Stuart (2012) noted that surgery may be recommended if a pancreatic cancer is found at an early stage and is located only within or around the pancreas.  The author also noted that surgery is the only treatment for pancreatic cancer.  After patients recover from surgery, normally six month of chemotherapy is recommended.  This treatment has proven to lower the risk of recurrent cancer (Nugent & Stuart, 2012).
1.6              Prognosis
Nugent and Stuart (2012) also mentioned in their article that only about 20 percent of patients undergoing a surgery procedure for curable pancreatic cancer live five years, others surviving on average less than two years.  Nugent and Stuart (2012) added for patients with incurable pancreatic cancer, survival is even shorter.  With metastatic disease (stage IV), the average survival is just over six months. 



3.      DISCUSSION
      
      The pancreas has a head with an uncinate process, a neck, a body and a tail (Lumley, Craven, & Aitken, 1987).  In normal CT images of the pancreas, Ryan and McNicholas (1994) reported that the tail is visible at the splenic hilum on the highest slices and the uncinate process is the lowest part.  Normal thickness of the head is 2cm, the neck 0.5 – 1 cm and the body and tail 1 – 2 cm (Ryan & McNicholas, 1994).  The height of the head is very variable and may measure up to 8 cm and the body and tail may measure 3 – 4 cm (Ryan & McNicholas, 1994).  However, for this patient, the normal anatomy area of the pancreas is altered by the large mass. 
      Radiologist, Dr Asokan Raman Nair (personal communication, November 20, 2012) interpret that there is a large mass arising from the tail of pancreas.  Figure 14 shows first slice of CT images that shows beginning of pancreatic mass.  The mass in this image only measure 2.0 x 3.1 cm.  The mass at the tail of the pancreas can be seen clearly at figure 16 measures 6.1 x 4.6 cm.  Because of the mass cover the whole tail of the pancreas, the normal structure of tail of the pancreas cannot be seen.  In the normal anatomy images, the tail of pancreas is the narrowed left extremity and lies in the lienorenal ligament (Lumley et al. 1987).  The tail lies with the splenic vessels between two layers of the lienorenal ligament and reaches the hilus of the spleen (Lumley et al. 1987).  Other than that, the radiologist noted that this mass is predominantly cystic with thickened enhancing walls.  This can be seeing clearly in figure 32.  The attenuation value or Hounsfield unit (HU) for the mass is approximately 15 to 25 and the enhancing wall surrounded the mass is approximately 80.  According to Molteni (2011), HU for water is 0, blood is +40 and muscle also +40.  Clearly, the mass is cystic like what radiologist reported and the thickened wall surrounded the mass probably either blood or just muscle-like tissue. 
      The mass from the tail of the pancreas extends to the body of the pancreas shows in image 18 reported by radiologist.  Here it is measured 8.1 x 6.1 cm.  He also noted that large pancreatic mass at the body of the pancreas can be seen in figure 29 which measured 11.8 x 7.6 cm. Like a tail, the body structure of the pancreas also cannot be seen because of the mass.  In normal radiograph of the pancreas, the body is triangular in section and has anterior, inferior, and posterior surfaces (Lumley et al. 1987).  Lumley et al. (1987) noted that its anterior surface is related to stomach and lesser omentum, inferior surface is related to the duodenojejunal flexure and coils of jejunum, and the transverse mesocolon is attached to the border between the anterior and inferior surfaces.  As shows in figure 29, radiologist showed from right to left, the mass at the body lies on the aorta, superior mesenteric artery, the left crus of the diaphragm, the left renal gland, and anterior surface of the left kidney.
      However, radiologist reported that the pancreatic head is normal as shown in figure 32.  Even though there is still large mass at the body of the pancreas, the mass does not cover the head of the pancreas.  Other than that, in figure 38, radiologist reported, uncinate process of the pancreas also appears normal.  In normal radiograph, the head is the expanded right extremity of the gland bearing inferiorly an uncinate process which passes to the left (Lumley et al. 1987).  Just like in figure 32 where the radiologist reports the normal appearance of the head, Lumley et al. (1987) also noted that anteriorly from above downwards the head is covered by the pylorus, the transverse colon, and coils of small intestine as shown in figure 66.  Figure 72 show posteriorly the head lies on the inferior vena cava, the right renal vessels, and bile duct. 
      Radiologist reported there is no appearance of the mass start from figure 42.  Meaning the mass end at the figure 41 where the size of the mass is 4.5 x 5.4 cm located inferior to transverse colon at the level of L2 L3.  From the radiologist, he noted that anteriorly this mass extends to the anterior abdominal wall and posteriorly this mass extends to the para-aortic area encasing the left renal artery and renal vein as shown in coronal section of CT images figure 51 and figure 77.
      Because of the pancreatic mass, radiologist reported that the stomach is displaced superomedially and compressed as show in coronal section image 57.  The stomach shows in this CT images is filled with oral contrast medium.  Lumley et al. (1987) described the normal anatomy of the stomach, it is usually J shape and situated in the left hypochondrium and epigastrium, its lower part extending to the level of the umbilicus.  The stomach is divided into fundus, a body and a pyloric portion (Lumley et al, 1987).  The fundus is the part above the level of esophageal opening; the body extends from the fundus to the angular notch and the pyloric portion from the notch to the pyloric sphincter.  The abnormal anatomy of this patient’s stomach is compared with normal anatomy from other patient from axial section of the CT images.  Figure 17 shows body of the stomach compressed by the mass and the diameter is only 1.6 cm compare with figure 83 which shows normal shape of the stomach which is 5.9 cm in diameter.  Figure 13 shows fundus part of the stomach is 4.6 cm in diameter while in normal images from other patient is 6.6 cm in diameter.  This different in diameter is due to compression of the mass to the stomach.  Figure 32 shows pyloric part of the stomach which is shifted, displaced and compressed, compared with figure 81 which shows normal position of pyloric part of the stomach.  Apart from this, radiologist reported there is no clear plane of demarcation between this mass and the greater curvature of the stomach. 
      Other affected organ is liver.  Radiologist reported there are multiple liver lesions in both lobes of the liver in keeping with liver metastasis.  Liver metastasis is a cancerous tumor that has spread to the liver. According to radiologist, liver is divided into two lobes, right and left lobes, and there are eight segments of the liver.  Ryan and McNicholas (1994) described, right lobe is divided into five segments which are segment four (medial superior and medial inferor), segment five (anterior inferior), segment six (posterior inferior), segment seven (posterior superior), and segment eight (anterior superior) while left lobe is divided into two segments which are segment two (lateral superior) and segment three (lateral inferior).  Segment one is located at caudate lobe (Ryan & McNicholas, 1994). 
      In this CT images, radiologist noted that there are tumor in segment four and segment two of the liver.  This can be seen in figure 12.  Radiologist reported the largest tumor is in segment two measuring 8.6 x 5.3 cm.  Tumor in segment two showed in figure 12 until figure 18 while tumor in segment four showed in figure 12 until figure 20.  In figure 20, CT image shows only small tumor measuring 1.4 x 1.4 cm.  Other than that, there are also tumors in segment five which can see from figure 26 until figure 28. There are two tumors in segment five of the liver show in figure 27.  The anterior tumor is 2.8 x 2.7 cm and posterior tumor is 2.2 x 2.6 cm.  Other than tumor, there is also metastasis in segment five of the liver which can be seen clearly in figure 32 to figure 37 measuring 5.9 x 4.2 cm.  Radiologist also stated that metastasis in segment six of the liver appear in figure 30 measuring 5.0 x 4.9 cm and can be seen until figure 44.
      In discussion with radiologist, noted that Hounsfield unit for normal liver area for this patient is around 124 HU.  However, Leblanc (2012) stated that HU scale for normal liver is 40 to 60.  This difference in HU is due to contrast medium.  Radiologist measure HU of the liver with contrast enhanced while Leblanc (2012) measure HU of the liver without contrast enhanced.  Due to contrast enhanced, HU for organ will increase.  Each tumor and metastasis in patient’s liver has difference HU reading.  For this patient, HU reading for tumor in segment two is about 84 and tumor in segment 4 is about 47.  Another two tumors in segment five are 41 HU and 87 HU.  Metastasis in segment five shows HU reading about 55 and in segment six shows 64 HU.  Radiologist noted that they usually compare the HU reading with  HU of water which is zero.  With reference to water, radiologist can interpret whether the tumor or metastasis is either cystic or solid. 
      From secondary cancer in the lymph nodes (2011), the author wrote that cancer cells can travel in the lymphatic system to nearby lymph nodes to another part of the body.  When cancer grows inside lymph nodes, it usually affects the lymph nodes near the tumor itself.  These nodes are the one that have been trying to filter out or kill the cancer cells (secondary cancer in the lymph nodes, 2011).  According to radiologist, when there is cancer, lymph nodes can get larger.  Radiologist noted that in normal patient, lymph nodes are usually tiny and very hard to find in CT images.  Like in this patient, several lymph nodes become larger because of pancreatic cancer.  Meaning, cancer has spread to the lymph nodes.  Radiologist reported that several lymph nodes that have been affected in this patient are retrocrural lymph node, paraaortic lymph node, paracaval lymph node, celiac lymph node, and portal lymph node.  Retrocrural lymph node showed in figure 23 until figure 28 measuring 1.1 x 2.7 cm.  It is situated between the spine and abdominal aorta in retrocrural space.  Another affected node is paraaortic lymph node.  It is situated in front of the spine near the aorta.  This can be seen from figure 29 until figure 40.  The large paraaortic lymph nodes showed in figure 34 measuring 4.3 x 3.3 cm.  Other than that, paracaval lymph nodes showed in figure 35 measuring less than one centimeter which situated near the aorta and inferior vena cava.  Celiac lymph nodes also measuring less than one centimeter showed in figure 27 near the celiac axis.  The last node noted is portal lymph node situated anterior to portal vein measuring 4.5 x 3.1 cm.  This can be seen in figure 26 to figure 31. 
      Radiologist reported that other organ like spleen is normal.  The spleen is seen as homogenously enhancing and there is no metastasis showed.  Other than that radiologist noted that the spleen size in this CT images look normal which showed from figure 8 until figure 26 located in the left hypochondrium posterior to pancreatic mass.  According to Ryan and McNicholas (1994), the spleen is enlarged if anterior to the aorta or extending below the ribs.  On CT, normal size of the spleen is difficult to define because respiratory movement between cuts, but it is assessed by the number of cuts on which the spleen is visible (Ryan & McNicholas, 1994). 
      Gallbladder is also normal as reported by radiologist.  Gallbladder images can be seen in figure 34 until figure 38.  Lumley et al. (1987) noted that the gallbladder is a pear-shaped sac lying in the right hypochondrium on the visceral surface of the right lobe of the liver.  However in CT images of this patient, radiologist noted that gall bladder looks a little bit compressed measuring 1.5 x 6.0 cm.  This is obvious when compared to other images from normal patient showed in figure 80 measuring 2.6 x 1.9 cm.  Radiologist noted that this maybe due to pancreatic mass which compressed the stomach and subsequently the stomach compressed gallbladder.    
      Both adrenals and right kidney appeared normal as reported by radiologist.  However, radiologist reported that for the left kidney there is fluid surrounding the left kidney as canbe seen in figure 29 and 30.  The fluid could be blood, urine or lymph.  Based on the attenuation value of the fluid which is 47, radiologist suggests it is perinephric fluid.  According to Ryan and McNicholas (1994) for normal patient, on CT the kidney is seen to be surrounded by perinephric fat and this is most abundant medial to the lower pole of the kidney and this is a favoured site of accumulation of blood, urine or pus in ruptured kidney.  Apart from that, other structures of the kidneys look normal.  The size of this patient’s kidneys showed in axial plane of CT images 6.0 x 5.3 cm.   Ryan and McNicholas (1994) suggested that in CT images for normal patient, at the hilum the kidney measures 5.0 x 4.0 cm which when compared to this patient’s kidney size is more or less the same and acceptable.
      Other abnormal thing that occurred and altered the normal anatomy of the area in cancer patient is ascites.  Radiologist reported that there is minimal ascites present.  According to radiologist, ascites is an accumulation of fluid in the peritoneal cavity, located in the space between tissue lining and abdominal organ.  This can be due to liver disease and metastasis.  Attenuation value for ascites in the images is 28 HU which is according to radiologist, it is exudative ascites because the HU is more than 15.  From ascites (2012), exudates ascites is defined as ascites with a protein content of greater than 3g protein per 100ml of fluid and possible causes of exudates ascites include malignant disease.    Radiologist also stated that there is ascites fluid around the liver as seen from figure 11 until figure 30.  The thickest ascites is showed in figure 16.  Other than that there is ascites fluid around the spleen also.  This can be seen in figure 11 until figure 27.  There is also ascites present between the abdominal lining and the stomach showed in figure 13 to figure 19.  Other than ascites, radiologist also noted that there is no pleural effusion present in early slice of the CT abdomen which showed lung segment from figure 7 until figure 17.  According to radiologist, if no pleural effusion noted meaning there is no metastasis to the lung yet.  From pleural effusion (2012), pleural effusion is excess fluid that accumulates between the two pleural layers, the fluid-filled space that surrounds the lungs.  Common causes of pleural effusion are pneumonia, cancer, viral infection, and pulmonary embolism (pleural effusion, 2012).
      Arterial and venous involvement also plays important roles.  For this patient, there are some which are abnormal because of pancreatic mass.  These are splenic artery and splenic vein.  Radiologist noted that splenic vein is thrombosed which showed in figure 18.  Splenic vein is the blood vessel that drains blood from the spleen.  Radiologist mentioned, thrombosis of the splenic vein means that there is a formation of a blood clot inside that blood vessels, obstructing the flow of the blood.  Tan and Thomson (2005) stated that splenic vein thrombosis is usually associated with acute pancreatitis, chronic pancreatitis and pancreatic cancer.  Other than that, radiologist reported that splenic artery is encased with infiltration.  This is due to pancreatic mass.  The mass is completely encasing the splenic artery showed from image 20 to image 26.  Splenic artery supplies oxygenated blood to the spleen.  Other arteries and veins are considered normal as suggested by radiologist. 
      Because cancer already spread to the other organ, patient can only go for chemotherapy as a treatment to pancreatic cancer.  Chemotherapy is a treatment that uses drugs to stop the growth of cancer cells, either by killing or by stopping them from dividing (Nugent & Stuart, 2012).  Talk about prognosis, for metastatic disease, doctors estimated the survival rate is about ten percent and within six month.  However, without active treatment, metastatic pancreatic cancer patient has a survival rate of approximately three month only.

  


4.      CONCLUSION
      From Tummala, Junaidi, and Agarwal (2011), the authors noted that pancreatic cancer is the fourth leading cause of cancer-related death in the United States.  Recent research shows the median size of pancreatic carcinoma at the time of diagnosis is about 3.1 cm and has not changed much in last three decades even though there is increasing major advances in imaging technology that can help diagnose smaller tumors (Tummala et al, 2011).  This is because most of pancreatic cancer patients are asymptomatic till late and have unclear symptoms.    
      Takhar (2004) noted that great improvements in non-invasive cross sectional radiological imaging in the past decade have greatly enhanced the ability to diagnose pancreatic cancer and help doctors to plan appropriate treatment for patients.  Other than that, accurate radiological staging of the diseases also allows for appropriate clinical decision making and ensures that surgery is limited to those patients who will benefit.
      Transabdominal ultrasound is often the first imaging modality used.  However, the current method of choice for diagnosis and staging of pancreatic cancer is contrast enhanced computed tomography where CT provides better tumor definition than does ultrasound (Takhar, 2004). 
      CT scan plays an important role for patients with suspected pancreatic carcinoma where it can confirm the stage tumor and can determine if tumor is resectable or not (Francis, 2004). Other than that, it also can detect the presence of distant disease (metastases), local tumor extension, documented regional or distant lymph node metastases, and arterial invasion or encasement of major arteries (Francis, 2004).  However, according to Francis (2004), CT scan also have some limitations where its inability to detect metastases to normal sized lymph nodes, small peritoneal metastases, less than 1cm hepatic metastases and subtle peripancreatic tumor extension. 

Increased awareness of pancreatic cancer amongst the clinicians and knowledge of the available imaging modalities and their optimal use in evaluation of patients suspected to have pancreatic cancer can potentially help in diagnosing more early stage tumors (Tummala, 2011). 

  
5.      REFERENCES
Lumley, J.S.P., Craven, J.L., & Aitken, J.T. (1987). Essential anatomy (4th ed.). London:         Churchill Livingstone.
Ryan, S., & McNicholas, M. (1994). Anatomy for diagnostic imaging (1st ed.). London:           Saunders.
Francis, I.R. (2004). Role of CT in detection and staging of pancreatic adenocarcinoma.          Cancer Imaging, 4(1), 10 – 14. doi: 10.1102/1470-7330.2003.0026
Molteni, R. (2011). From CT Numbers To HU In Cone Beam Volumetric Imaging. Retrieved             December 10, 2012, from www.aaomr.org/resource/resmgr/annual/aaomr   2011_medium.pdf
Takhar, A.S., Palaniappan, P., Dhingsa, R., & Lobo, D.N. (2004). Recent developments in      diagnosis of pancreatic cancer. BMJ, 329(7467), 668 – 673. Retrieved from        http://www.ncbi.nlm.nih.gov/pmc/articles/PMC517650/
Tummala, P., Junaidi, O., & Agarwal, B. (2011). Imaging of pancreatic cancer: An overview. J Gasrointest Oncol, 2(3), 168 – 174. doi: 10.3978/j.issn.2078-6891.2011.036
Dragovich, T. (2012) Pancreatic Cancer.  Retrieved November 17, 2012, from       emedicine.medscape.com/article/280605-overview
Leblanc, E. (2012). Hounsfield Unit. Retrieved December 12, 2012, from       www.wikiradiography.com/page/housfield++unit
Nugent, F.W. & Stuart, K.E. (2012) Pancreatic Cancer. Retrieved December 06, 2012, from       www.medicinenet.com › ... › cancer az list  pancreatic cancer index
Ascites. (2012). Retrieved December 10, 2012 from        en.wikipedia.org/wiki/Ascites
Pancreatic Cancer. (2012). Retrieved November 15, 2012, from           en.wikipedia.org/wiki/Pancreatic_cancer
Pancreatic Cancer Symptoms, (2012). Retrieved December 06, 2012, from       http://www.webmd.com/cancer/pancreatic-cancer/pancreatic-cancer-symptoms
Pancreatic Carcinoma. (2012). Retrieved  November 15, 2012, from       http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001283/
Pancreatic Carcinoma. (2012). Retrieved November 17, 2012, from health.nytimes.com         › Times Health Guide  p
Pleural Effusion. (2012). Retrieved December 10, 2012 from     en.wikipedia.org/wiki/Pleural_effusion
Secondary Cancer In The Lymph Nodes. (2011). Retrieved December 12, 2012 from       http://www.macmillan.org.uk
Splenic Vein. (2012). Retrieved December 10, 2012 from en.wikipedia.org/wiki/Splenic_vein 
The Pancreas. (2011). Retrieved November 17, 2012, from       www.pancreaticalliance.org/panca/index.html
What Causes Pancreatic Cancer. (2012). Retrieved November 17, 2012, from       pathology.jhu.edu/pc/BasicCauses.php
What is Pancreatic Cancer? Pancreatic Cancer Stmptoms and Causes. (2012). Retrieved        November 15, 2012, from www.medicalnewstoday.com/info/pancreatic-cancer/